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Figure 10 | Journal of Neuroinflammation

Figure 10

From: Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation

Figure 10

Schematic showing the possible mode of action of honokiol. LPS stimulation results in the overexpression of Klf4 and pNF-κB in microglial cells, which migrate to the nucleus and enhance the promoter activities of proinflammatory genes, thereby resulting in microglial activation. HNK inhibits the expression of these transcription factors as well as iNOS and Cox-2 promoter activities in LPS-stimulated microglial cells. HNK also suppresses the production of neuroinflammatory molecules, including TNF-α, MCP-1 and IL-6. In addition, HNK blocks NO production and ROS generation from activated microglia.

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