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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation

Figure 4

Inducible nitric oxide synthase and cyclooxygenase-2 promoter assay in response to lipopolysaccharide and honokiol. Luciferase assay from total protein extracts from pGL2-iNOS and pCOX301 transfected, LPS- and HNK-treated BV-2 cells. (A) Decrease in iNOS promoter activities upon stimulation with different doses of HNK with respect to LPS-treated condition. (B) Decrease in Cox-2 promoter activities upon stimulation with 10 μM HNK in comparison to LPS-treated condition. Graphs represent relative luciferase units normalized to protein levels. Data represent mean ± SEM from three independent experiments performed in duplicate. *P < 0.05 and **P < 0.01 in comparison to LPS-treated values.

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