Figure 5
From: Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation
Effect of honokiol on the expression levels of phospho-NF-κB and Krüppel-like factor 4 in BV-2 cells. Total cellular extract isolated from cells treated with 500 ng/mL of LPS and different doses of HNK for 12 hours were analyzed by immunoblotting for Klf4 and pNF-κB levels. (A) Decrease in pNF-κB levels upon treatment with different doses of HNK. (B) Significant decrease in Klf4 levels upon treatment with different doses of HNK. The graphs represent fold change in protein levels relative to untreated controls. Data represent mean ± SEM from three independent experiments performed in duplicate. *P < 0.05 and **P < 0.01 in comparison to LPS-treated values.