Figure 6
From: Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation
Effect of honokiol on the expression levels of phospho-NF-κB and Krüppel-like factor 4 in vivo. Brain homogenate from BALB/c mice treated with different doses of HNK and 5 mg/kg body weight of LPS analyzed by immunoblotting for Klf4 and pNF-κB levels. (A) Significant decrease in the levels of pNF-κB in 2.5 as well as 5 mg/kg body weight dose of HNK with respect to LPS-treated mice. (B) Significant decrease in Klf4 levels in 2.5 as well as 5 mg/kg body weight HNK doses with respect to LPS-control mice. Graphs represent fold change in protein levels with respect to untreated control condition. Data represent mean ± SEM of five animals in each group. *P < 0.05 and **P < 0.01 in comparison to LPS-treated values.