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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation

Figure 8

Honokiol-mediated reduction in microglial activation in vivo. Cryostat sections from BALB/c mice treated with different doses of HNK and 5 mg/kg body weight of LPS, analyzed by immunohistochemistry. (A) Fluorescent images of brain section from control mice showing microglia in their 'resting' morphology. (B) Images showing the an increase in the number of 'activated' microglia in response to LPS as shown by an arrow. (C, D) Images from mice treated with 2.5 mg/kg body weight of HNK (C) and 5 mg/kg body weight of HNK (D) showing microglia with resting stage morphology similar to the control condition, marked by a small arrow. Images show the staining for Iba-1 (fluorescein isothiocyanate, green), DAPI (blue) and merged images (right panel). Scale bar: 50 μm.

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