Figure 3
From: Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection
Infection of mice with viable scrapie-experimental autoimmune encephalomyelitis immune cells shortened the prion disease incubation period. (A) PrPSc levels in brains and immune samples. (B) EAE clinical scores in mice inoculated with viable or homogenated cells after activation ex vivo for three days with MOG. (C) Survival curves of mice infected with the designated inocula. The survival curve of group 1 was significantly different (P < 0.05) as compared to survival curves of groups 2,3,4 and 6. Results represent eight to ten mice in each category.