Table 1 Microarray analysis on hypothalamus of 10-week-old Nestin-Pex5 ^−/− mice

Complement

Fold change

C3ar1

complement component 3a receptor 1

11.28 ^***

C1qb

complement component 1, q subcomponent, beta polypeptide

9.4 ^***

C4b

complement component 4B

8.47 ^***

C1qa

complement component 1, q subcomponent, alpha polypeptide

7.64 ^***

Chemokines

Cxcl13

chemokine (C-X-C motif) ligand 13

16.8 ^***

Ccl6

chemokine (C-C motif) ligand 6

11.93 ^***

Ccl3

chemokine (C-C motif) ligand 3

8.13 ^***

IL12b

Interleukin 12b

5.67 ^***

Leukocyte transedothelial migration

Itgb2

Integrin beta 2

5.57 ^***

Itgam

Integrin alpha M

3.56 ^***

ICAM1

Intercellular adhesion molecule 1

4.12 ^***

VCAM1

Vascular cell adhesion molecule 1

1.52 ^***

Antigen processing and presentation

H2-K1

Histocompatibility 2, K1, K region

5.57 ^***

H2-D1

Histocompatibility 2, D region locus 1

3.56 ^***

Fcgr2b

Fc receptor, IgG, low affinity IIb

6.21 ^***

Fcgr3

Fc receptor, IgG, low affinity III

4.41 ^***

P2Y6

Pyrimidinergic receptor P2Y, G-protein coupled 6

5.22 ^***

B2m

beta-2 microglobulin

3.06 ^***

Ctse

cathepsin E

1.52 ^***

Toll-like receptor signaling pathway

TLR2

Toll-like receptor 2

4.70 ^***

TLR1

Toll-like receptor 1

4.43 ^***

TLR7

Toll-like receptor 7

1.98 ^***

TLR4

Toll-like receptor 4

1.70 ^***

Anti-inflammatory markers

IL4

Interleukin 4

0.93

IL10

Interleukin 10

1.03

IL13

Interleukin 13

1.01

Arg1

Arginase-1

1.13

TGFβ

Transforming growth factor β

2.54 ^***

HO-1

Heme oxygenase-1

2.37 ^***

Anti-oxidantia

Cat

Catalase

1.23 ^*

MnSOD

Manganese superoxide dismutase

0.95

Prdx6

Peroxiredoxin 6

1.34 ^***

Prdx1

Peroxiredoxin 1

1.12 ^*

Gpx1

Glutathione peroxidase 1

1.25 ^***