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Table 1 Microarray analysis on hypothalamus of 10-week-old Nestin-Pex5 −/− mice

From: Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

Cytokine-cytokine receptor interaction
Complement   Fold change
C3ar1 complement component 3a receptor 1 11.28 ***
C1qb complement component 1, q subcomponent, beta polypeptide 9.4 ***
C4b complement component 4B 8.47 ***
C1qa complement component 1, q subcomponent, alpha polypeptide 7.64 ***
Chemokines
Cxcl13 chemokine (C-X-C motif) ligand 13 16.8 ***
Ccl6 chemokine (C-C motif) ligand 6 11.93 ***
Ccl3 chemokine (C-C motif) ligand 3 8.13 ***
IL12b Interleukin 12b 5.67 ***
Leukocyte transedothelial migration
Itgb2 Integrin beta 2 5.57 ***
Itgam Integrin alpha M 3.56 ***
ICAM1 Intercellular adhesion molecule 1 4.12 ***
VCAM1 Vascular cell adhesion molecule 1 1.52 ***
Antigen processing and presentation
H2-K1 Histocompatibility 2, K1, K region 5.57 ***
H2-D1 Histocompatibility 2, D region locus 1 3.56 ***
Fcgr2b Fc receptor, IgG, low affinity IIb 6.21 ***
Fcgr3 Fc receptor, IgG, low affinity III 4.41 ***
P2Y6 Pyrimidinergic receptor P2Y, G-protein coupled 6 5.22 ***
B2m beta-2 microglobulin 3.06 ***
Ctse cathepsin E 1.52 ***
Toll-like receptor signaling pathway
TLR2 Toll-like receptor 2 4.70 ***
TLR1 Toll-like receptor 1 4.43 ***
TLR7 Toll-like receptor 7 1.98 ***
TLR4 Toll-like receptor 4 1.70 ***
Anti-inflammatory markers
IL4 Interleukin 4 0.93
IL10 Interleukin 10 1.03
IL13 Interleukin 13 1.01
Arg1 Arginase-1 1.13
TGFβ Transforming growth factor β 2.54 ***
HO-1 Heme oxygenase-1 2.37 ***
Anti-oxidantia
Cat Catalase 1.23 *
MnSOD Manganese superoxide dismutase 0.95
Prdx6 Peroxiredoxin 6 1.34 ***
Prdx1 Peroxiredoxin 1 1.12 *
Gpx1 Glutathione peroxidase 1 1.25 ***
  1. Only the most affected KEGG pathways are represented. Values are given as means of 4 independent samples. * p < 0.05, *** p < 0.001.