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Table 2 Fold change of mRNA levels of inflammatory mediators incorpus callosum and cerebellum of 6-week-old Nestin-Pex5 mice

From: Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

Nestin-Pex5 6 weeks

Fold change

Corpus callosum

Cerebellum

TNFα

28.96 ± 6.27***

17.15 ± 8.85

C1q

8.40 ± 1.43***

2.94 ± 1.45

TLR2

11.91 ± 3.26***

12.42 ± 6.10

Mpeg1

13.64 ± 6.38***

10.63 ± 0.34***

TGFβ

2.83 ± 0.18***

3.38 ± 0.5**

IL10

30.92 ± 10.65*

3.18 ± 3.10

Arg1

1.78 ± 0.08**

2.78 ± 1.11

Fizz1

13.31 ± 8.59

1.62 ± 0.50

  1. Values represent means of 4 independent samples. * p < 0.05, ** p < 0.01, *** p < 0.001. Expression levels were normalized to β-actin expression.