Figure 1

SCI was suppressed more in IL-1 KO than in wild-type mice. (A) Motor function determined according to the Basso Mouse Scale improved in a time-dependent manner after SCI in wild-type (open circles) and IL-1 KO mice (closed squares). The score for IL-1 KO mice is significantly improved compared to the wild-type from the 3rd dpo. Numbers in parentheses indicate sample numbers at each time point. Data are expressed as mean ± SE. **: P <0.01 (Student's t-test). (B) Representative images of GFAP-immunostaining after SCI. The injured area as defined by GFAP-positive cells is relatively smaller in IL-1 KO mice than in the wild-type. (C) The injured area is significantly suppressed in IL-1 KO mice (n = 5 to 7, filled bars) at the 7th and the 14th dpo compared to wild-type (n = 7 to 10, open column). Data are expressed as mean ± SE. **: P <0.01 (Student's t-test). dpo, days post-operatively; GFAP, glial fibrillary acidic protein; SCI, spinal cord injury.