FK866 treatment reduces astrocyte and microglial activation after SCI. Spinal cord sections revealed increased astrogliosis (GFAP + cells) in the perilesional area after SCI (b). On the contrary, a significant number of non-GFAP positive cells were found in the spinal cord from FK866 (c) treated mice. Moreover, microglial cells were activated following SCI as shown by increased CD11b-positive staining (e). Expression of CD11b was attenuated by FK866 (f) treatment. In panel g densitometric analysis is reported. *p < 0.01 vs sham, °p < 0.01 vs SCI + vehicle.