Effects of FK866 on TNF-α and IL-1β release and on MPO activity. A substantial increase in TNF-α (a) and IL-1β (b) production was found in spinal cord tissue collected from SCI mice at 24 h. Spinal cord levels of TNF-α and IL-1β were significantly attenuated by the FK866. Moreover, MPO activity in spinal cord of untreated SCI-operated mice was significantly increased at 24 h after the damage in comparison to sham mice (c). Treatment with FK866 significantly reduced the SCI-induced increase in MPO activity. Data are means ± S.E.M of 10 mice for each group. *p < 0.01 vs sham, °p < 0.01 versus SCI + vehicle.