Skip to main content
Figure 1 | Journal of Neuroinflammation

Figure 1

From: Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus

Figure 1

Effect of BBG, OxATP and A-438079 on I/R-induced neuronal damage in the hippocampal CA1 region. (A) Representative H&E staining of hippocampal CA1 neurons from the sham group, saline group, BBG 10 μg group, OxATP 1 μg and A-438079 3 μg groups at the seventh day (+7D) (left) and representative TUNEL of hippocampal CA1 neurons from the sham group, saline group, BBG 10 μg group, OxATP 1 μg and A-438079 3 μggroups at the third day (+3D). (B) Neuron survival rate in the hippocampal CA1 region in BBG 1 μg, 5 μg and 10 μg groups at +7D. (C) Neuronal survival rate in the hippocampal CA1 region in OxATP 1 μg, 5 μg and 10 μg groups at +7D. (D) Neuronal survival rate in the hippocampal CA1 region in the A-438079 0.03 μg, 0.3 μg and 3 μg groups at +7D. (E) The percentage of TUNEL-positive neurons in the hippocampal CA1 region in the sham, saline, BBG 10 μg, OxATP 1 μg and A-438079 3 μg groups at +3D. Values are expressed as the mean ± S.E.M. All photomicrographs are × 400. Scale bar: 10 μm. **P < 0.01 versus saline group; * P < 0.05 versus saline group; ##P < 0.01 versus sham group; # P < 0.05 versus sham group. (n = 6 in all the groups). BBG, Brilliant blue G; I/R, ischemia/reperfusion; OxATP, adenosine 5′-triphosphate-2′,3′-dialdehyde; S.E.M., standard error of the mean; TUNEL, deoxynucleotidyl transferase-mediated UTP nick end labeling.

Back to article page