Figure 3

Effect of BBG, OxATP and A-438079 on spatial learning and memory in the water maze. (A) Escape latency to find the platform during the five days of thetraining trial from the eighth day (+8D) to the twelfth day (+12D) after reperfusion. (B) Time spent during the probe trial in the quadrant where the platform had been located. Values are expressed as the mean ± S.E.M. *P < 0.05 versus the corresponding value of thesaline group on the same day; **P < 0.01 versus the corresponding value of the saline group on the same day; #P < 0.05 versus the corresponding value of the sham group on the same day; ##P < 0.01 versus the corresponding value of the sham group on the same day; + P < 0.05 versus the corresponding value of the OxATP 1 μg group on the same day; ++P < 0.01 versus the corresponding value of the OxATP 1 μg group on the same day (n = 15, 14, 13, 13, 10 in sham, saline, BBG 10 μg, OxATP 1 μg, A-438079 3 μg groups, respectively). BBG, Brilliant blue G; OxATP, adenosine 5′-triphosphate-2′,3′-dialdehyde; S.E.M., standard error of the mean.