Figure 3From: IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci BBB permeability does not correlate with onset of atypical disease. Representative Evans blue infiltrated areas of the cerebella/brainstems and spinal cords of the various groups of mice at EAE onset. CNS areas showing Evans blue staining (see Additional file 2) were cut transversely and photographed using a Zeiss stereoscope. Two (out of 4-6) representative mice per group are shown. IFNγ-/- (A-D), IFNγRKO-chimeras (I-L) and IFNγRperiKO (U-X) exhibited substantial Evans blue staining both in cerebellum and spinal cord. Evans blue staining patterns in the WT (E-H), WT-chimeras (Q-T) and IFNγRCNSKO (M-P) were meningeal and confined in small areas in the spinal cord and were rarely detected in the cerebellum/brainstem parenchyma. Numbers in pink and white denote atypical and classic neurological deficits, respectively.Back to article page