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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury

Figure 4

Trichostatin A (TSA) treatment reduces white and grey matter injury in female, but not male, neonates at 5 days afterlipopolysaccharide-sensitised hypoxia-ischaemia (LPS/HI). (A) Grey matter tissue loss (%) in male and female LPS/HI and LPS + TSA/HI mice at 5 days after HI (all n = 12). (B) and (D) Total volume of grey matter tissue loss (B) and subcortical white matter loss (D) in male and female LPS/HI and LPS + TSA/HI at 5 days after HI. (C) and (E) Representative images of microtubule-associated protein 2 (MAP-2)-stained whole hemispheres (C) and myelin basic protein (MBP)-stained subcortical white matter (E) in female LPS/HI and female LPS + TSA/HI mice at 5 days after HI. Data are means ± SEM. *P < 0.05 by Student’s t-test.

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