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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury

Figure 7

Neonatal trichostatin A (TSA) treatment altered open-field behaviours and improved learning in young adulthood after lipopolysaccharide-sensitised hypoxia-ischaemia (LPS/HI).(A) Representative trace recordings from LPS/HI- and LPS + TSA/HI-treated mice. (B) Output from the multivariate partial least squares discriminant analysis (PLS-DA) of open-field data illustrating significant differences between LPS/HI- and LPS + TSA/HI-treated mice in young adulthood. Each point represents the cumulative value for all behavioural variables for one individual, and red circles represent female LPS/HI. Green squares represent female LPS + TSA/HI. The y-axis is for visualisation purposes only and should not be overinterpreted. The statistics are described further in the Materials and methods section. (C) Trace fear-conditioning data illustrating time spent immobile (frozen) pretone and after exposure to the fear-conditioned stimulus (light and tone) on day 2 (n = 15 to 19). Data are means ± SEM. *P<0.05 by post hoc Student’s t-test.

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