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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice

Figure 2

Morphological changes of Iba1-immunoreactive cells in the hilus of dentate gyrus of hippocampus. The upper panels show examples of the five morphological types in which Iba1-immunoreactive cells were classified: Type I, cells with few cellular processes (two or less); Type II, cells showing four short branches; Type III, cells with numerous cell processes and a small cell body; Type IV, cells with large somas and retracted and thicker processes and Type V, cells with amoeboid cell body, numerous short processes and intense Iba1 immunostaining. The graph shows the proportion of each morphological type in non-stressed (NS) and prenatally stressed (PS) animals treated with vehicle (VEH) or LPS. aaa, Significant difference (P <0.001) of II type cells versus PS-VEH, NS-LPS and PS-LPS mice. bbb, Significant difference (P <0.001) of III type cells between NS-VEH, NS-LPS and PS-LPS mice. ccc, Significant difference (P <0.001) of type IV cells between NS-VEH mice. ddd, Significant difference (P <0.001) of type IV cells versus PS-LPS mice. eee, Significant difference (P <0.01) of type IV cells versus PS-VEH mice. ff, Significant difference versus NS-VEH and PS-VEH mice.

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