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Figure 2 | Journal of Neuroinflammation

Figure 2

From: A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi

Figure 2

B. burgdorferi induces CCL2, IL-6 and IL-8 in MO3.13 oligodendrocytes in a dose dependent fashion. Evaluation by the multiplex ELISA assay of culture supernatants of differentiated MO3.13 oligodendrocytes incubated with live B. burgdorferi spirochetes at a multiplicity of infection (MOI) of 10:1, and 100:1 for 48 h show elevated levels of CCL2 (A), IL-6 (B), and IL-8 (C) as compared to that observed in medium controls (* P < 0.05, ** P < 0.01).

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