The specific inducible nitric oxide synthase (iNOS) inhibitor
-(3-(aminomethyl)benzyl)acetamidine (1400 W) abrogated the decrease of hole-searching time induced by unpredictable chronic mild stress (UCMS). Mice were subjected to various stressors in the presence or absence of the iNOS inhibitor 1400 W for 4 weeks. Hole-searching time was recorded in the locomotor activity test. Data are mean ± SEM (n = 8 for control; n = 6 for stress; n = 8 for stress + 1400 W). **
P <0.01 for each comparison.