The specific inducible nitric oxide synthase (iNOS) inhibitor
-(3-(aminomethyl)benzyl)acetamidine (1400 W) had no effect on the unpredictable chronic mild stress (UCMS)-induced increase of central time and total travel distance. Mice were subjected to various stressors in the presence or absence of the iNOS inhibitor 1400 W for 4 weeks. Central time and total travel distance were recorded for 5 minutes: (A) central time; (B) total travel distance. Data are mean ± SEM (n = 10 for control; n = 10 for stress; n = 9 for stress + 1400 W). *
P <0.05, **
P <0.01 compared to control.