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Table 1 Summary of genes most strongly regulated by lesion only or SRF-VP16

From: Serum response factor modulates neuron survival during peripheral axon injury

 

Lesion-specific genes

SRF-VP16-specific genes

 

Gene name

Gene symbol

Up

Gene name

Gene symbol

Up

1

Small proline-rich protein 2J

Sprr2j

80.1

Actin, alpha, cardiac

Actc1

13.2

2

G protein-coupled receptor 151

Gpr151

31.0

Protein phosphatase with EF hand

Ppef1

12.2

3

Activating transcription factor 3

Atf3

28.6

Tissue inhibitor of metalloprot. 1

Timp1

12.2

4

Glutamate receptor, metab. 3

Grm3

24.9

Ankyrin repeat domain 1

Ankrd1

10.3

5

Protein phosphatase with EF

Ppef1

19.9

Calponin 1

Cnn1

9.5

6

Galanin

Gal

19.8

Coagulation factor II receptor-like 2

F2rl2

8.7

7

Tissue inhibitor of metalloprot. 1

Timp1

14.3

Actin, alpha 2, smooth muscle

Acta2

7.9

8

Neuropeptide Y

Npy

13.2

Transgelin (Sm22)

Tagln

6.4

9

Annexin a10

Anxa10

12.7

Apolipoprotein L 7b | L 7e

Apol7b/e

4.7

10

Small proline-rich protein 2 J

Sprr2j

12.7

Serine (or cysteine) peptidase inh.

Serpine1

4.5

11

Tubulin, beta 6

Tubb6

11.4

T-box18

Tbx18

3.8

12

Ankyrin repeat domain 1

Ankrd1

11.4

Interleukin 1 receptor, type II

Il1r2

3.8

13

Wingless related 2b

Wnt2b

10.6

Actinin alpha 3

Actn3

3.7

14

A disintegrin and metallopept. 8

Adam8

9.5

Angiopoietin-like 2

Angptl2

3.4

15

S100 calcium binding prot. A11

S100a11

9.2

Insulin-like growth fac. bind. prot. 6

Igfbp6

3.2

16

Xanthine dehydrogenase

Xdh

8.7

Follistatin

Fst

3.2

17

Anthrax toxin receptor 2

Antxr2

8.5

GLI pathogenesis-related 1

Glipr1

3.1

18

SH2 domain protein 1B2

Sh2d1b2

8.4

Solute carrier family 38, member 8

Slc38a8

2.9

19

Gastrin releasing peptide

Grp

7.5

Early growth response 1

Egr1

2.7

20

Vasoactive intestinal polypeptide

Vip

7.4

Dihydroxyacetone kinase 2 hom.

Dak

2.7

21

Protein C receptor, endothelial

Procr

6.9

Tuftelin 1

Tuft1

2.6

22

Integrin alpha 7

Itga7

6.8

Serum response factor

Srf

2.4

23

Lymphocyte antigen 86

Ly86

6.8

Bone marrow stromal cell antigen 1

Bst1

2.4

24

Nerve growth factor

Ngf

6.5

Dopamine receptor 2

Drd2

2.4

25

Integrin alpha M

Itgam

6.1

Desmocollin 3

Dsc3

2.3

26

Prokineticin receptor 2

Prokr2

6.0

Blood vessel epicardial substance

Bves

2.2

27

Serine (or cysteine) pept. inh.

Serpine1

5.9

ALX homeobox 1

Alx1

2.2

28

G protein-coupled receptor 133

Gpr133

5.7

Neuronal pentraxin 2

Nptx2

2.2

29

Cyclin-dep. kinase inh.1A (P21)

Cdkn1a

5.6

Glucagon-like peptide 1 receptor

Glp1r

1.9

30

GalaninCD180 antigen

Cd180

5.4

Regulator of G-protein signaling 4

Rgs4

1.7