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Figure 1 | Journal of Neuroinflammation

Figure 1

From: The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation

Figure 1

Age-related microglial activation in hippocampus is attenuated by URB597. URB597 attenuated the age-related increase in MHCII mRNA, CD68 mRNA, and CD11b mRNA in hippocampal tissue and the analysis revealed a significant age x treatment interaction for MHCII mRNA (F(1,22) = 8.84, **P < 0.01; 2-way ANOVA; a), CD11b mRNA (F(1,22) = 6.22, *P < 0.05; b), and CD68 mRNA (F(1,22) = 4.80, *P < 0.05; c). A significant age effect was observed in the case of CD40 mRNA (F(1,21) = 14.09, ++ P < 0.01; d).

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