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Figure 3 | Journal of Neuroinflammation

Figure 3

From: The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation

Figure 3

URB597 treatment attenuates age-related changes in cortex. Increased expression of MHCII, CD11b, CD68, and CD40 mRNA were observed in cortex of aged, compared with young, rats. A significant age x treatment effect in the case of MHCII mRNA (F(1,23) = 9.11, **P < 0.01; 2-way ANOVA; a) and significant age effects were observed in the case of CD11b (F(1,20) = 44.86, +++ P < 0.001; b), CD68 (F(1,22) = 14.81, +++ P < 0.001; c) and CD40 mRNA (F(1,20) = 5.62, + P < 0.05; d). Significant age effects were also observed in IL-1β (F(1,22) = 5.97, + P < 0.05; 2-way ANOVA; e), TNFα (F(1,23) = 9.98, ++P < 0.01; f) and IL-6 (F(1,26) = 20.91, ++ P < 0.01; g).

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Journal of Neuroinflammation

ISSN: 1742-2094