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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice

Figure 1

JWH oral administration rescued the cognitive impairment of TgAPP. Cannabinoid agonists did not alter the discrimination of the novel object (NO) compared to the familar one (A) of wt mice. Tg APP failed to distinguish the NO, like those treated with WIN, but JWH treatment restored normal discrimination. Animals were treated with vehicle or cannabinoids (0.2 mg/kg) in the drinking water for 4 months, starting at 7 months of age. Time spent exploring either objects was expressed as percentage of the total exploration time. Results are mean ± SEM (5-7 mice/group). *p < 0.05 vs familiar object (ANOVA followed by Student's t test).

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