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Table 1 Cytokine, chemokine and colony stimulating factor concentrations in prenatal maternal serum

From: Maternal immune activation by poly(I:C) induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain

  6 h after injection 24 h after injection
  Control poly(I:C) % change ↑ or ↓ Control poly(I:C) % change ↑ or ↓
Pro- and anti-inflammatory cytokines         
 IL-1α  386.3 ± 123.3 260.0 ± 1.9 38 308.8 ± 90.0 160 ± 78.3 38
 IL-1β  3.6 ± 1.0 7.0 ± 0.2 97 ↑* 1.5 ± 0.2 7.9 ± 5.1 736
 IL-2  0.7 ± 0.2 1.1 ± 0.2 70 ND 0.4 ± 0.3 ND
 IL-3  0.5 ± 0.1 0.6 ± 0.3 26 ND 0.8 ± 0.8 ND
 IL-4  0.1 ± 0.0 0.2 ± 0.3 25 ND 0.6 ± 0.6 ND
 IL-5  8.5 ± 4.5 14.4 ± 1.4 69 1.9 ± 0.6 3.8 ± 0.7 84
 IL-6  1.6 ± 0.1 96.6 ± 48.0 5935 1.3 ± 0.3 5.4 ± 2.7 478
 IL-7  3.2 ± 1.3 1.4 ± 0.2 58 3.5 ± 1.0 7.1 ± 6.1 305
 IL-9  20.0 ± 9.8 51.7 ± 3.8 158 ↑* 12.6 ± 7.4 32.7 ± 24.6 216
 IL-12(p40)  5.3 ± 2.8 47.4 ± 10.3 789 ↑* 2.4 ± 0.4 6.2 ± 3.4 214
 IL-12(p70)  3.2 ± 1.2 12.6 289 ↑* 0.6 ± 0.3 8.4 ± 6.7 3236
 IL-13  30.7 ± 7.8 271.8 ± 19.9 784 ↑** 44.5 ± 13.7 45.0 ± 14.9 3  
 IL-15  52. ± 2.3 34.8 ± 5.1 570 ↑** 3.4 ± 1.7 7.1 ± 4.0 116
 IL-17  2.0 ± 0.5 3.2 ± 0.8 63 1.0 ± 0.1 2.9 ± 2.3 343
 IFN-γ 1.4 ± 04 4.8 ± 0.9 253 ↑* 1.6 ± 0.1 4.3 ± 2.5 309
 TNF-α  1.9 ± 0.6 13.6 ± 1.5 626 ↑** 1.2 ± 0.2 4.1 ± 1.7 266
 IL-10  4.0 ± 1.2 52.8 ± 7.2 1210 ↑** 3.0 ± 0.2 10.4 ± 2.0 250 ↑*
 LIF  2.5 ± 1.1 4.3 ± 1.4 74 ND 0.6 ± 0.0 ND ↑*
Chemokines         
 Eotaxin  86.0 ± 26.6 333.3 ± 93.9 287 ↑* 59.2 ± 10.1 70.0 ± 23.2 30
 MCP-1  5.4 ± 0.3 1154.0 ± 432.3 21400 ↑* 5.5 ± 0.4 48.2 ± 24.9 976
 MIP-1α  7.4 ± 3.9 66.2 ± 5.5 802 ↑** 1.8 ± 0.9 11.6 ± 5.2 559 ↑*
 MIP-1β  14.9 ± 5.0 456.0 ± 112.5 2986 ↑* 5.1 ± 0.6 23.3 ± 7.3 533
 RANTES  6.9 ± 3.6 1640.7 ± 735.6 23700 ↑* 5.0 ± 2.4 89.1 ± 27.3 569 ↑*
 IP-10  22.8 ± 3.7 2089.0 ± 518.5 9049 ↑* 25.3 ± 4.6 180.6 ± 28.5 1476 ↑*
 KC  17.1 ± 2.9 64.3 ± 25.4 276 ↑* 12.7 ± 2.8 15.1 ± 7.4 52
 LIX  1818.7 ± 598.1 1640.3 ± 481.8 10 1451.0 ± 483.7 1277.7 ± 501.7 1
 MIG  34.7 ± 1.9 1855 ± 144.8 5259 ↑** 75.8 ± 25.8 1932.1 ± 867.7 2012 ↑*
 MIP-2  46.5 ± 8.8 96.0 ± 1.7 108 ↑** 25.3 ± 3.3 42.8 ± 17.5 168
Colony stimulating factors         
 GM-CSF  4.4 ± 0.3 12.1 ± 2.5 174 ↑* 10.0 ± 6.1 6.9 ± 2.9 32
 G-CSF  165.7 ± 32.7 2906.7 ± 678.8 1654 ↑* 109.7 ± 26.9 1823.6 ± 778.4 2003 ↑*
 M-CSF  2.0 ± 0.8 11.4 ± 1.9 468 ↑* 0.8 ± 0.1 3.8 ± 1.9 465
 VEGF  0.5 ± 0.1 1.3 ± 0.0 185 ↑** 0.5 ± 0.1 0.5 ± 0.1 6