6h after injection | 24h after injection | |||||||
---|---|---|---|---|---|---|---|---|
Control | poly(I:C) | % change | ↑ or ↓ | Control | poly(I:C) | % change | ↑ or ↓ | |
Pro- and anti-inflammatory cytokines | ||||||||
IL-1α | ND | ND | ND | ND | ND | ND | ||
IL-1β | 43.9 ± 3.5 | 46.5 ± 9.6 | 6 | ↑ | 94.9 ± 5.3 | 126.9 ± 11.3 | 34 | ↑* |
IL-2 | ND | ND | ND | ND | ND | ND | ||
IL-3 | ND | ND | ND | ND | ND | ND | ||
IL-4 | ND | ND | ND | ND | ND | ND | ||
IL-5 | ND | ND | ND | ND | ND | ND | ||
IL-6 | ND | ND | ND | ND | ND | ND | ||
IL-7 | 1.2 ± 0.1 | 3.7 ± 0.9 | 205 | ↑* | 3.4 ± 0.8 | 3.9 ± 1.7 | 23 | ↑ |
IL-9 | 101.9 ± 3.3 | 108.5 ± 5.6 | 7 | ↑ | 128.1 ± 3.1 | 125.3 ± 3.3 | 2 | ↓ |
IL-12(p40) | ND | ND | ND | ND | ND | ND | ||
IL-12(p70) | ND ± | ND ± | ND | ND | ND | ND | ||
IL-13 | 3.8 ± 0.9 | 17.3 ± 5.5 | 356 | ↑* | 4.1 ± 0.7 | 9.6 ± 2.9 | 136 | ↑ |
IL-15 | ND | ND | ND | 9.7 ± 1.1 | 7.9 ± 1.0 | 19 | ↓ | |
IL-17 | ND | ND | ND | 7.7 ± 0.5 | 7.1 ± 1.3 | 8 | ↓ | |
IFN-γ | ND | ND | ND | ND | ND | ND | ||
TNF-α | ND | ND | ND | ND | ND | ND | ||
IL-10 | 27.7 ± 1.4 | 25.3 ± 2.5 | 9 | ↓ | 23.8 ± 1.6 | 27.5 ± 2.7 | 15 | ↑ |
LIF | ND | ND | ND | ND | ND | ND | ||
Chemokines | ||||||||
Eotaxin | 18.7 ± 1.1 | 22.5 ± 2.5 | 20 | ↑ | 35.0 ± 3.5 | 32.6 ± 2.8 | 6 | ↓ |
MCP-1 | 13.8 ± 1.5 | 25.0 ± 5.9 | 81 | ↑ | 6.8 ± 0.5 | 21.7 ± 6.9 | 218 | ↑* |
MIP-1α | 300.3 ± 8.7 | 261.5 ± 9.7 | 13 | ↓** | 153.6 ± 11.7 | 280.0 ± 47.7 | 82 | ↑** |
MIP-1β | ND | ND | ND | 3.4 ± 0.5 | 2.3 ± 0.6 | 31 | ↓ | |
RANTES | ND | ND | ND | 1.5 ± 0.1 | 1.7 ± 0.5 | 14 | ↑ | |
IP-10 | 23.2 ± 2.1 | 60.5 ± 3.4 | 160 | ↑** | 26.3 ± 2.1 | 41.1 ± 3.5 | 56 | ↑** |
KC | ND | ND | ND | 1.8 ± 0.1 | 1.7 ± 0.1 | 4 | ↓ | |
LIX | ND | ND | ND | ND | ND | ND | ||
MIG | 11.3 ± 2.9 | 17.2 ± 2.2 | 52 | ↑* | 49.0 ± 2.4 | 39.3 ± 3.3 | 20 | ↓* |
MIP-2 | ND | ND | ND | ND | ND | ND | ||
Colony stimulating factors | ||||||||
GM-CSF | ND | ND | ND | 2.4 ± 0.7 | 1.3 ± 0.6 | 47 | ↓ | |
G-CSF | ND | ND | ND | ND | ND | ND | ||
M-CSF | ND | ND | ND | 3.7 ± 0.1 | 2.9 ± 1.1 | 21 | ↓ | |
VEGF | 0.9 ± 0.0 | 2.4 ± 0.5 | 177 | ↑* | 1.8 ± 0.2 | 1.9 ± 0.3 | 7 | ↑ |