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Table 2 Cytokine, chemokine and colony stimulating factor concentrations in prenatal brain homogenates

From: Maternal immune activation by poly(I:C) induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain

 

6h after injection

24h after injection

 

Control

poly(I:C)

% change

↑ or ↓

Control

poly(I:C)

% change

↑ or ↓

Pro- and anti-inflammatory cytokines

        

 IL-1α 

ND

ND

ND

 

ND

ND

ND

 

 IL-1β 

43.9 ± 3.5

46.5 ± 9.6

6

94.9 ± 5.3

126.9 ± 11.3

34

↑*

 IL-2 

ND

ND

ND

 

ND

ND

ND

 

 IL-3 

ND

ND

ND

 

ND

ND

ND

 

 IL-4 

ND

ND

ND

 

ND

ND

ND

 

 IL-5 

ND

ND

ND

 

ND

ND

ND

 

 IL-6 

ND

ND

ND

 

ND

ND

ND

 

 IL-7 

1.2 ± 0.1

3.7 ± 0.9

205

↑*

3.4 ± 0.8

3.9 ± 1.7

23

 IL-9 

101.9 ± 3.3

108.5 ± 5.6

7

128.1 ± 3.1

125.3 ± 3.3

2

 IL-12(p40) 

ND

ND

ND

 

ND

ND

ND

 

 IL-12(p70) 

ND ±

ND ±

ND

 

ND

ND

ND

 

 IL-13 

3.8 ± 0.9

17.3 ± 5.5

356

↑*

4.1 ± 0.7

9.6 ± 2.9

136

 IL-15 

ND

ND

ND

 

9.7 ± 1.1

7.9 ± 1.0

19

 IL-17 

ND

ND

ND

 

7.7 ± 0.5

7.1 ± 1.3

8

 IFN-γ 

ND

ND

ND

 

ND

ND

ND

 

 TNF-α 

ND

ND

ND

 

ND

ND

ND

 

 IL-10 

27.7 ± 1.4

25.3 ± 2.5

9

23.8 ± 1.6

27.5 ± 2.7

15

 LIF 

ND

ND

ND

 

ND

ND

ND

 

Chemokines

        

 Eotaxin 

18.7 ± 1.1

22.5 ± 2.5

20

35.0 ± 3.5

32.6 ± 2.8

6

 MCP-1 

13.8 ± 1.5

25.0 ± 5.9

81

6.8 ± 0.5

21.7 ± 6.9

218

↑*

 MIP-1α 

300.3 ± 8.7

261.5 ± 9.7

13

↓**

153.6 ± 11.7

280.0 ± 47.7

82

↑**

 MIP-1β 

ND

ND

ND

 

3.4 ± 0.5

2.3 ± 0.6

31

 RANTES 

ND

ND

ND

 

1.5 ± 0.1

1.7 ± 0.5

14

 IP-10 

23.2 ± 2.1

60.5 ± 3.4

160

↑**

26.3 ± 2.1

41.1 ± 3.5

56

↑**

 KC 

ND

ND

ND

 

1.8 ± 0.1

1.7 ± 0.1

4

 LIX 

ND

ND

ND

 

ND

ND

ND

 

 MIG 

11.3 ± 2.9

17.2 ± 2.2

52

↑*

49.0 ± 2.4

39.3 ± 3.3

20

↓*

 MIP-2 

ND

ND

ND

 

ND

ND

ND

 

Colony stimulating factors

        

 GM-CSF 

ND

ND

ND

 

2.4 ± 0.7

1.3 ± 0.6

47

 G-CSF 

ND

ND

ND

 

ND

ND

ND

 

 M-CSF 

ND

ND

ND

 

3.7 ± 0.1

2.9 ± 1.1

21

 VEGF 

0.9 ± 0.0

2.4 ± 0.5

177

↑*

1.8 ± 0.2

1.9 ± 0.3

7