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Table 2 Cytokine, chemokine and colony stimulating factor concentrations in prenatal brain homogenates

From: Maternal immune activation by poly(I:C) induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain

  6h after injection 24h after injection
  Control poly(I:C) % change ↑ or ↓ Control poly(I:C) % change ↑ or ↓
Pro- and anti-inflammatory cytokines         
 IL-1α  ND ND ND   ND ND ND  
 IL-1β  43.9 ± 3.5 46.5 ± 9.6 6 94.9 ± 5.3 126.9 ± 11.3 34 ↑*
 IL-2  ND ND ND   ND ND ND  
 IL-3  ND ND ND   ND ND ND  
 IL-4  ND ND ND   ND ND ND  
 IL-5  ND ND ND   ND ND ND  
 IL-6  ND ND ND   ND ND ND  
 IL-7  1.2 ± 0.1 3.7 ± 0.9 205 ↑* 3.4 ± 0.8 3.9 ± 1.7 23
 IL-9  101.9 ± 3.3 108.5 ± 5.6 7 128.1 ± 3.1 125.3 ± 3.3 2
 IL-12(p40)  ND ND ND   ND ND ND  
 IL-12(p70)  ND ± ND ± ND   ND ND ND  
 IL-13  3.8 ± 0.9 17.3 ± 5.5 356 ↑* 4.1 ± 0.7 9.6 ± 2.9 136
 IL-15  ND ND ND   9.7 ± 1.1 7.9 ± 1.0 19
 IL-17  ND ND ND   7.7 ± 0.5 7.1 ± 1.3 8
 IFN-γ  ND ND ND   ND ND ND  
 TNF-α  ND ND ND   ND ND ND  
 IL-10  27.7 ± 1.4 25.3 ± 2.5 9 23.8 ± 1.6 27.5 ± 2.7 15
 LIF  ND ND ND   ND ND ND  
Chemokines         
 Eotaxin  18.7 ± 1.1 22.5 ± 2.5 20 35.0 ± 3.5 32.6 ± 2.8 6
 MCP-1  13.8 ± 1.5 25.0 ± 5.9 81 6.8 ± 0.5 21.7 ± 6.9 218 ↑*
 MIP-1α  300.3 ± 8.7 261.5 ± 9.7 13 ↓** 153.6 ± 11.7 280.0 ± 47.7 82 ↑**
 MIP-1β  ND ND ND   3.4 ± 0.5 2.3 ± 0.6 31
 RANTES  ND ND ND   1.5 ± 0.1 1.7 ± 0.5 14
 IP-10  23.2 ± 2.1 60.5 ± 3.4 160 ↑** 26.3 ± 2.1 41.1 ± 3.5 56 ↑**
 KC  ND ND ND   1.8 ± 0.1 1.7 ± 0.1 4
 LIX  ND ND ND   ND ND ND  
 MIG  11.3 ± 2.9 17.2 ± 2.2 52 ↑* 49.0 ± 2.4 39.3 ± 3.3 20 ↓*
 MIP-2  ND ND ND   ND ND ND  
Colony stimulating factors         
 GM-CSF  ND ND ND   2.4 ± 0.7 1.3 ± 0.6 47
 G-CSF  ND ND ND   ND ND ND  
 M-CSF  ND ND ND   3.7 ± 0.1 2.9 ± 1.1 21
 VEGF  0.9 ± 0.0 2.4 ± 0.5 177 ↑* 1.8 ± 0.2 1.9 ± 0.3 7