Table 3 Cytokine, chemokine and colony stimulating factor concentrations in postnatal brain homogenates
24 h after injection | ||||
|---|---|---|---|---|
Control | poly(I:C) | % change | ↑ or ↓ | |
Pro- and anti-inflammatory cytokines | ||||
IL-1α | ND | ND | ||
IL-1β | 64.5 ± 4.5 | 68.1 ± 3.5 | 6 | ↑ |
IL-2 | 0.8 ± 0.1 | 1.1 ± 0.1 | 42 | ↑* |
IL-3 | 1.1 ± 0.1 | 2.1 ± 0.3 | 82 | ↑** |
IL-4 | ND | ND | ||
IL-5 | ND | ND | ||
IL-6 | 9.5 ± 0.5 | 7.9 ± 0.8 | 17 | ↓ |
IL-7 | 6.9 ± 0.5 | 5.1 ± 0.7 | 25 | ↓* |
IL-9 | 129.6 ± 1.8 | 118.8 ± 4.2 | 8 | ↓* |
IL-12(p40) | ND | ND | ||
IL-12(p70) | ND | ND | ||
IL-13 | 19.7 ± 1.3 | 33.1 ± 2.5 | 68 | ↑** |
IL-15 | 19.5 ± 0.9 | 19.3 ± 1.9 | 1 | ↓ |
IL-17 | 4.6 ± 0.3 | 5.9 ± 0.5 | 28 | ↑* |
IFN-γ | ND | ND | ||
TNF-α | ND | ND | ||
IL-10 | 22.3 ± 0.7 | 21.3 ± 1.7 | 4 | ↓ |
LIF | ND | ND | ||
Chemokines | ||||
Eotaxin | 27.8 ± 1.2 | 33.8 ± 2.7 | 22 | ↑* |
MCP-1 | 6.5 ± 0.5 | 69.4 ± 23.0 | 962 | ↑** |
MIP-1α | 81.4 ± 10.2 | 83.9 ± 7.2 | 3 | ↑ |
MIP-1β | 5.8 ± 0.5 | 8.5 ± 0.8 | 47 | ↑* |
RANTES | 1.5 ± 0.2 | 5.1 ± 1.2 | 235 | ↑** |
IP-10 | 22.1 ± 1.3 | 251.0 ± 39.9 | 1037 | ↑** |
KC | 3.3 ± 0.2 | 4.6 ± 0.6 | 41 | ↑* |
LIX | ND | ND | ||
MIG | 38.3 ± 1.5 | 115.3 ± 19.3 | 201 | ↑** |
MIP-2 | 4.1 ± 0.3 | 5.2 ± 0.5 | 26 | ↑* |
Colony stimulating factors | ||||
GM-CSF | 4.9 ± 0.4 | 6.6 ± 0.9 | 36 | ↑* |
G-CSF | 1.4 ± 0.1 | 1.7 ± 0.2 | 24 | ↑* |
M-CSF | 4.7 ± 0.1 | 5.2 ± 0.4 | 11 | ↑ |
VEGF | 1.1 ± 0.1 | 0.9 ± 0.1 | 24 | ↓* |