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Table 3 Cytokine, chemokine and colony stimulating factor concentrations in postnatal brain homogenates

From: Maternal immune activation by poly(I:C) induces expression of cytokines IL-1β and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain

  24 h after injection
  Control poly(I:C) % change ↑ or ↓
Pro- and anti-inflammatory cytokines     
 IL-1α  ND ND   
 IL-1β  64.5 ± 4.5 68.1 ± 3.5 6
 IL-2  0.8 ± 0.1 1.1 ± 0.1 42 ↑*
 IL-3  1.1 ± 0.1 2.1 ± 0.3 82 ↑**
 IL-4  ND ND   
 IL-5  ND ND   
 IL-6  9.5 ± 0.5 7.9 ± 0.8 17
 IL-7  6.9 ± 0.5 5.1 ± 0.7 25 ↓*
 IL-9  129.6 ± 1.8 118.8 ± 4.2 8 ↓*
 IL-12(p40)  ND ND   
 IL-12(p70)  ND ND   
 IL-13  19.7 ± 1.3 33.1 ± 2.5 68 ↑**
 IL-15  19.5 ± 0.9 19.3 ± 1.9 1
 IL-17  4.6 ± 0.3 5.9 ± 0.5 28 ↑*
 IFN-γ ND ND   
 TNF-α  ND ND   
 IL-10  22.3 ± 0.7 21.3 ± 1.7 4
 LIF  ND ND   
Chemokines     
 Eotaxin  27.8 ± 1.2 33.8 ± 2.7 22 ↑*
 MCP-1  6.5 ± 0.5 69.4 ± 23.0 962 ↑**
 MIP-1α  81.4 ± 10.2 83.9 ± 7.2 3
 MIP-1β  5.8 ± 0.5 8.5 ± 0.8 47 ↑*
 RANTES  1.5 ± 0.2 5.1 ± 1.2 235 ↑**
 IP-10  22.1 ± 1.3 251.0 ± 39.9 1037 ↑**
 KC  3.3 ± 0.2 4.6 ± 0.6 41 ↑*
 LIX  ND ND   
 MIG  38.3 ± 1.5 115.3 ± 19.3 201 ↑**
 MIP-2  4.1 ± 0.3 5.2 ± 0.5 26 ↑*
Colony stimulating factors     
 GM-CSF  4.9 ± 0.4 6.6 ± 0.9 36 ↑*
 G-CSF  1.4 ± 0.1 1.7 ± 0.2 24 ↑*
 M-CSF  4.7 ± 0.1 5.2 ± 0.4 11
 VEGF  1.1 ± 0.1 0.9 ± 0.1 24 ↓*