Figure 3
From: Preventive immunization of aged and juvenile non-human primates to beta-amyloid
Concentrations in cerebrospinal fluid of amyloid and tau proteins (A–C) Concentrations of (A) Aβ40, (B) Aβ42 and (C) total tau before (week 0) and after (week 16) immunization. Bars represent median and interquartile range. No significant differences were seen between aged (n = 9) and juvenile animals (n = 8) or between baseline and post-immunization levels for either cohort. (D) However, a composite score, the tau:Aβ42 ratio showed a significant difference between juvenile and aged animals after, but not before, vaccination.