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Table 2 Baseline Aβ 40 , Aβ 42 and total tau levels in cerebrospinal fluid and plasma of juvenile and aged NHPs (median and interquartile range)

From: Preventive immunization of aged and juvenile non-human primates to beta-amyloid

 

Juvenile animals (n = 19)

Aged animals (n = 16)

P -value

Cerebrospinal fluid

  Aβ40, pg/ml

1494 (923 to 2077)

1514 (971 to 2145)

NS

  Aβ42, pg/ml

78.4 (65.3 to 118.4)

107.4 (59.8 to 162.1)

NS

  Tau, pg/ml

131.4 (89.4 to 168.2)

249.0 (94.2 to 345.2)

0.06

  Tau/Aβ42

1.48 (0.84 to 1.94)

1.84 (1.20 to 3.40)

NS

Plasma

  Aβ40, pg/ml

16.0 (15.1 to 21.0)

15.1 (11.4 to 18.8)

NS

  Aβ42, pg/ml

ND

ND

 
  1. ND, not detected; NS, not significant.