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Table 3 Post-mortem ELISA Aβ42 levels and histopathologic evaluation of amyloid and tau pathology of immunized and non-immunized aged non-human primates

From: Preventive immunization of aged and juvenile non-human primates to beta-amyloid

Animal ID (age, years) (species, sex) Immune response 42content frontal Cx, pg/ml Diffuse plaques Neuritic plaques Vascular amyloid Neuro fibrillary tangles Other pathologic findings
Immunized animals
CW06-423 (22) (R, M) H BD 0 0 0 0 Colon carcinoma
CW07-220 (22) (R, F) H BD 0/+ (frontal and insular cortex) 0/+ (insular cortex) + 0 Mild liver steatosis
CW07-221 (21) (R, F) H BD 0 0 0 0 Multilocular biliary liver cysts; mild lung emphysema
CW07-222 (21) (R, F) H BD 0/+ (frontal cortex); + (caudate head) 0/+ (caudate head) 0 0 Non-necrotizing granulomatous lung disease
CW08-237 (20) (P, F) H BD 0 0 0 0 0
CW06-422 (20) (R, M) L BD 0 0 0 0 ND
CW08-236 (20) (P, F) L BD 0 0 0 0 Renal cortical cysts
CW08-238 (18) (P, F) L 22.17 ++ (patchy frontal cortex); 0/+ (CA1, entorhinal, temporal, insular cortex) ++ (frontal cortex); 0 0 Papillary renal cell carcinoma; focal atypical adenomatous hyperplasia of the lung
CW07-223 (26) (C, F) N BD 0/+ (frontal cortex) 0 0 0 ND
CW08-239 (20) (P, F) N BD + (caudate head) + (caudate head) 0 0 0
Non-immunized animals      
CW06-420 (18) (C, M) N/A BD 0/+ (frontal cortex) 0 0 ++ (subiculum); + (CA1, frontal cortex) ND
CW06-421 (18) (C, M) N/A 24.61 + (frontal and temporal cortex) 0 0/+ 0 Renal oncocytoma; renal cortical cysts; needle tract injury of the spinal cord
CW08-232 (18) (R, M) N/A BD 0 0 0 0 ND
CW08-233 (19) (R, M) N/A BD 0 0 0 0 Organizing eosinophilic pneumonia
CW08-234 (21) (R, M) N/A BD 0/+ (frontal cortex) 0 0 0 ND
CW08-235 (19) (R, M) N/A BD 0 0 0 0 ND
  1. 0, absent; 0/+, minimal; +, mild; ++, moderate (reflecting most severely affected area in each brain region); BD, below detection limit; C, cynomolgus macaque; Cx, cortex; F, female; H, high responder; L, low responder; M, male; N, non-responder; N/A, not applicable; ND, not done; P, pigtailed macaque; R, rhesus macaque.