Table 3 Post-mortem ELISA Aβ42 levels and histopathologic evaluation of amyloid and tau pathology of immunized and non-immunized aged non-human primates
From: Preventive immunization of aged and juvenile non-human primates to beta-amyloid
Animal ID (age, years) (species, sex) | Immune response | Aβ42content frontal Cx, pg/ml | Diffuse plaques | Neuritic plaques | Vascular amyloid | Neuro fibrillary tangles | Other pathologic findings |
|---|---|---|---|---|---|---|---|
Immunized animals | |||||||
CW06-423 (22) (R, M) | H | BD | 0 | 0 | 0 | 0 | Colon carcinoma |
CW07-220 (22) (R, F) | H | BD | 0/+ (frontal and insular cortex) | 0/+ (insular cortex) | + | 0 | Mild liver steatosis |
CW07-221 (21) (R, F) | H | BD | 0 | 0 | 0 | 0 | Multilocular biliary liver cysts; mild lung emphysema |
CW07-222 (21) (R, F) | H | BD | 0/+ (frontal cortex); + (caudate head) | 0/+ (caudate head) | 0 | 0 | Non-necrotizing granulomatous lung disease |
CW08-237 (20) (P, F) | H | BD | 0 | 0 | 0 | 0 | 0 |
CW06-422 (20) (R, M) | L | BD | 0 | 0 | 0 | 0 | ND |
CW08-236 (20) (P, F) | L | BD | 0 | 0 | 0 | 0 | Renal cortical cysts |
CW08-238 (18) (P, F) | L | 22.17 | ++ (patchy frontal cortex); 0/+ (CA1, entorhinal, temporal, insular cortex) | ++ (frontal cortex); | 0 | 0 | Papillary renal cell carcinoma; focal atypical adenomatous hyperplasia of the lung |
CW07-223 (26) (C, F) | N | BD | 0/+ (frontal cortex) | 0 | 0 | 0 | ND |
CW08-239 (20) (P, F) | N | BD | + (caudate head) | + (caudate head) | 0 | 0 | 0 |
Non-immunized animals | Â | Â | Â | Â | Â | ||
CW06-420 (18) (C, M) | N/A | BD | 0/+ (frontal cortex) | 0 | 0 | ++ (subiculum); + (CA1, frontal cortex) | ND |
CW06-421 (18) (C, M) | N/A | 24.61 | + (frontal and temporal cortex) | 0 | 0/+ | 0 | Renal oncocytoma; renal cortical cysts; needle tract injury of the spinal cord |
CW08-232 (18) (R, M) | N/A | BD | 0 | 0 | 0 | 0 | ND |
CW08-233 (19) (R, M) | N/A | BD | 0 | 0 | 0 | 0 | Organizing eosinophilic pneumonia |
CW08-234 (21) (R, M) | N/A | BD | 0/+ (frontal cortex) | 0 | 0 | 0 | ND |
CW08-235 (19) (R, M) | N/A | BD | 0 | 0 | 0 | 0 | ND |