Figure 1

Total home-cage locomotor activity was monitored for 24 hours at three separate time points: 15 and 22 days after poly(I:C) infusion, and 24 hours before animals were killed. No significant differences were seen between treatment groups at any of the time intervals. However, there was a trend towards reduced activity at the middle time point (22 days). Data are expressed as a mean ± SEM; n = 8 to 15 Analysis of pole-test performance was used to investigate any PD-like hindlimb and forelimb coordination deficits that might have been induced by paraquat with or without poly(I:C) priming. The pole test was conducted once, during the second week after saline/poly(I:C) infusion. Latency to turn and latency to pole descent were both recorded for three trials. No behavioral difference were found for either of the measures across treatment groups (Fs _(5,42) < 1, P > 0.05; data not shown).