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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus

Figure 5

Anti- and pro-apoptotic proteins expressed following saline, saline + LPS, saline + LT and LPS + LT injection in rat hippocampus. (A) Representative western blots showing the expression of the anti-apoptotic proteins Bcl2 and Bcl-XL at 24 hours after saline + LPS, saline + LT or LPS + LT injection. (B) Similar as in A but for the pro-apoptotic proteins Bax and Bak. Experiment were done in parallel and repeated four times with similar results. (C) Densitometric analysis of western blots. Results were normalized with β-actin and referred to saline-injected animals. Data are presented as mean ± SD compared to a pool of saline-injected young animals. *P <0.05. Bcl: B-cell lymphoma; LPS: lipopolysaccharide; LT: lactacystin; SD: standard deviation.

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Journal of Neuroinflammation

ISSN: 1742-2094