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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge

Figure 6

Gene expression analyses indicate increases in Th1 cytokines and microglia activation in multiple brain regions. To determine the extent that acute PS stimulated an inflammatory response, we conducted a time course examination of 4 brain regions and spleen. A one-way ANOVA and Tukey's post hoc revealed that both TNF and IL-1 were increased at respective time points following PS within the hypothalamus, hippocampus, and midbrain. Changes in the microglial activation marker CD45 were also increased within the hippocampus and midbrain, although not until 4 and 8 hrs after cessation, respectively. Changes in the prefrontal cortex and spleen are also provided. Columns that do not share the same letter are significantly different (One-way ANOVA; p < 0.05). Data are expressed as percent change from control and presented as Mean ± SEM. n = 6-8/group.

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