CXCL13 is the major determinant for B cell recruitment to the CSF during neuroinflammation

Table 3 Stepwise multiple regression

	Stepwise multiple regression				Predictor variables
	Model				*Variable*	*Beta*	P
	F	df	P	R ²
B cells all	21.650	3	0.000	0.391	CXCL13	0.745	0.000
					CXCL12	−0.490	0.001
					BAFF	0.320	0.012
B cells	18.098	2	0.000	0.262	CXCL13	0.616	0.000
					CXCL12	−0.271	0.010
Plasmablasts	20.265	2	0.000	0.287	CXCL13	0.413	0.000
					BAFF	0.234	0.009
T cells	6.001	2	0.003	0.110	BAFF	−0.498	0.001
					APRIL	0.296	0.05
Monocytes					No variables included

Stepwise multiple regression was applied to determine the most predictable cytokine/ chemokine for the presence of certain immune cells in the CSF. Variables (cytokines/ chemokines), which fulfilled the entry criteria of P <0.05 for the regression model, are displayed. For B cells and plasmablasts, CXCL13 turned out to be the most predictable chemokine.

ISSN: 1742-2094