Infection and upregulation of proinflammatory cytokines in human brain vascular pericytes by human cytomegalovirus

Table 1 Microarray results three days after SBCMV infection of brain vascular pericytes representing the highest fold change in transcription linked to neuroinflammation.

Genes upregulated	Fold change	Some associated functions
RSAD2	390	Protein directly induced by cytomegalovirus
ISG20	380	Interferon-stimulated exonuclease
CCL5	364	Chemotactic cytokine for activated T cells, eosinophils and basophils
CXCL11	337	Chemotactic cytokine for activated T cells
CCL5	141	Chemotactic cytokine for activated T cells, eosinophils and basophils
IFI27	117	Interferon alpha inducible gene/inflammation
TAC1	111	Neurotransmitter, induction of behavioral responses
CCL20	76	Chemotactic cytokine for lymphocytes and neutrophils
HERC5	60	Interferon-induced ubiquitin-E3 protein ligase
IL8	4	Chemotactic cytokine for neutrophils

CCL5, C chemokine (C-C motif) ligand 5; CCL20, chemokine (C-C motif) ligand 20; CXCL11, chemokine (C-X-C motif) ligand 11; HERC5, probable E3 ubiquitin-protein ligase HERC5; IFI27, interferon alpha-inducible protein 2; IL8, interleukin 8; ISG20, interferon-stimulated gene 20 kDa protein; RSAD2, radical S-adenosyl methionine domain-containing protein 2; TAC1, tachykinin precursor 1.

ISSN: 1742-2094