The effects of nicotine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced microglia activation in the mouse substantia nigra pars compacta (SNpc).
(A) Mac-1-IR microglia in mouse SNpc. Scale bar: 200 μm.
(B) Stereological cell counts of Mac-1-IR microglia in the mouse SNpc. Data are presented as a percentage of controls (mean ± SEM) from four to six mice per group. *P < 0.05 and **P < 0.01 versus the control (saline-only) group; ##
P < 0.01 versus the MPTP treatment group.