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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

Figure 6

Tumor necrosis factor-α protein from splenocytes isolated from Non-Tg and 3 × Tg mice. Splenocytes isolated from Non-Tg and 3 × Tg mice were cultured for 24 hours and TNFα levels measured by ELISA. 3,6′-DT-treated 3 × Tg mice had significantly reduced TNFα secretion compared with vehicle-treated 3 × Tg mice. One-way analysis of variance: P = 0.0184. *P < 0.05 versus 3 × Tg (vehicle). ELISA: enzyme-linked immunosorbent assay; 3,6′-DT: 3,6′-dithiothalidomide; Thal: thalidomide; TNFα: tumor necrosis factor-α.

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Journal of Neuroinflammation

ISSN: 1742-2094