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Table 1 Central nervous system-infiltrating peripheral blood-derived leukocytes

From: Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

 

% CD45hi

%CD45hi/Gr1+/Ly6Ghi

Intracellular TNFαa

   

CD45hi/Gr1+/Ly6Ghi

Non-Tg

6.7 ± 1.8

5.5 ± 2.0

-

-

3 × Tg

14.3 ± 4.9

13.9 ± 4.4

493 ± 197.7

88.5 ± 16.7

3 × Tg (3,6′-DT)

17.4 ± 1.9

13.6 ± 1.3

759 ± 75.3

28.3 ± 5.2

P

n.s.

n.s.

n.s.

0.0309

  1. aTNFα is expressed as a percentage increase from Non-Tg values. P-value is 3 × Tg versus 3 × Tg (3,6′-dithiothalidomide). Results are expressed as the mean ± standard error; n = 3 to 4 mice per group. n.s.: not significant; TNFα: tumor necrosis factor-α.