Enbrel reduced TNFα and IRS-1
phosphorylation, while increasing insulin receptor autophosphorylation. In all panels, data shows results for wildtype (WT) and β2KO (β2KO) mice only or WT and β2KO mice treated with etanercept. (A) Demonstrates that etanercept was effective in reducing TNFα levels, which are increased in β2KO only mice. (B) Shows that insulin receptor autophosphorylation sites tyrosine 1150/1151 are reduced in β2KO mice, which are restored after etanercept treatment. (C) Demonstrates that IRS-1Ser307 is reduced after etanercept treatment to β2KO mice. *P < 0.05 versus WT. #P < 0.05 versus β2KO only. Data are mean ± SEM. N = 5 mice for all groups.