Inhibition of TNFα with etanercept reduces suppressor of cytokine signaling 3 (SOCS3) and IR
levels. In all panels, data shows results for wildtype (WT) and β2KO (β2KO) mice only or WT and β2KO mice treated with etanercept. (A) Western blot data on SOCS3 levels demonstrating that etanercept reduced SOCS3 levels in β2KO mice. (B) Western blot data on insulin receptor phosphorylation on tyrosine 960, showing that IRTyr960 is reduced after etanercept treatment. *P < 0.05 versus WT. #P < 0.05 versus β2KO only. Data are mean ± SEM. N = 5 mice for all groups.