Etanercept treatment reduces pro-apoptotic markers. In all panels, data shows results for wildtype (WT) and β2KO (β2KO) mice only or WT and β2KO mice treated with etanercept. (A) and (B) show that etanercept increases anti-apoptotic markers Akt (A) and Bcl-xL (B), while (C-E) demonstrate the etanercept decreased pro-apoptotic markers Bax (C), Cytochrome C (D) and cleaved caspase 3 (E). *P < 0.05 versus WT. #P < 0.05 versus β2KO only. Data are mean ± SEM. N = 5 mice for all groups.