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Table 1 Monitoring of the mRNA autophagy marker levels in APPswePS1dE9

From: Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice

 

Wild-type

APPswePS1dE9

 

Cortex

Hippocampus

Cortex

Hippocampus

Beclin-1

1.00 ± 0.26

1.00 ± 0.18

1.22 ± 0.21

0.91 ± 0.05

p62

1.00 ± 0.12

1.00 ± 0.08

0.93 ± 0.12

1.10 ± 0.06

LC3

1.00 ± 0.07

1.00 ± 0.08

0.79 ± 0.05

0.82 ± 0.09

  1. Total RNA was isolated from cortex and hippocampus of 12-month old APPswePS1dE9 and WT mice and TaqMan real-time PCR was performed in an ABI 7500 real-time PCR system as described in Materials and methods. Results were normalized relatively to mean of WT mice (n = 12).
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Journal of Neuroinflammation

ISSN: 1742-2094