Synergistic effects of SCM-198 and donepezil on cognitive impairments in a chronic rat Alzheimer’s disease (AD) model induced by Aβ
. SD rats were subjected to bilateral microinjections of 2 μg/μl aggregated Aβ1-40 (5 μl/side) or vehicle into hippocampus and Morris water maze (MWM) test was conducted 50 days after surgery. (a) Mean escape latency from Day 1 to Day 4; (b) time spent in target quadrant. Data represent mean ± SEM of nine rats per group. *P < 0.05, **P < 0.01, Tukey’s test versus only Aβ1-40-treated group; #P < 0.05, ##P < 0.01, ###P < 0.001, Tukey’s test versus sham group.