Figure 1From: Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis Structure and purification of recombinant tau proteins followed by the immunization paradigm. (A) Schematic presentation of the sequence and commassie stain of recombinant full length tau protein (wild-type (Wt)-tau, 4R0N) or tau mutated at P301L (P301L-tau, 4R0N). (B) Non-transgenic and rTg4510 mice were immunized three times in alternating weeks, followed by a 10-week resting period, then boosted three times every 3 weeks. After the vaccination period, tissue and blood specimens were analyzed for cellular immune responses and neuropathological changes. Ab, antibody; MW, molecular weight.Back to article page