Figure 3From: Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis Cellular immune responses specific to different tau proteins were detected in rTg4510 mice following immunizations with wild-type (Wt)- or P301L-tau proteins. (A) Proliferation of T cells is detected by [3H]-thymidine incorporation assay in splenocyte cultures obtained from experimental and control animals and expressed as stimulation index. (B) Number of IFN-γ producing cells (spot formatting cells, SFC) is detected by ELISPOT assay in splenocyte cultures obtained from immunized rTg4510 mice. Bars represent average ± SD (n = 4).Back to article page