Figure 7

Vaccination with wild-type (WT)- or P301L-tau proteins reduced tau pathology. (A) Micrographs of brain regions (anterior cortex (ACX), hippocampus (HPC), and entorhinal cortex (ECX)) immunostained for total-tau (H150) and (B) AT8 (pS202-Thr205). (C) Analysis of percent positive area in each region demonstrated significant reduction of total tau in the animals immunized with Wt-tau, while (D) reduction in AT8 (pS202-Thr205) tau levels was observed in both groups as compared to phosphate-buffered saline (PBS)-injected animals. Values are normalized to PBS controls and student t-test was performed, *P < 0.05. Scale bar is 200 μm for regions, 20 μm for insets.