Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis

Table 1 Immunization paradigm and group assignment

Group	Mice	Immunogen	Number of mice	Route	Adjuvant
1	Littermate	Wt-Tau	4	Subcutaneous	Quil A
2	rTg4510	Wt-Tau	4	Subcutaneous	Quil A
3	Littermate	P310L-Tau	4	Subcutaneous	Quil A
4	rTg4510	P310L-Tau	4	Subcutaneous	Quil A
5	Littermate	PBS	4	Subcutaneous	Quil A
6	rTg4510	PBS	4	Subcutaneous	Quil A

rTg4510 mice (n = 12) and non-transgenic littermates (n = 12) were separated into 6 groups (n = 4 per group). Each mouse was subcutaneously injected with a mix solution of 1.1 mg/ml of each protein formulated in 2.0 mg/ml Quil A adjuvant. Each groups respective immunogen, immunization route, and adjuvant used are indicated. PBS, phosphate-buffered saline; Wt, wild-type.

ISSN: 1742-2094