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Figure 3 | Journal of Neuroinflammation

Figure 3

From: The immune response after hypoxia-ischemia in a mouse model of preterm brain injury

Figure 3

Brain injury after 70-minute hypoxia-ischemia (HI) insult. Dot graphs showing the volume difference between the contralateral and ipsilateral hemispheres in gray matter (A) and white matter (B) at 7 days after 70-minute HI in PND 5 mice (n = 13). *P < 0.05, ***P < 0.001 using Student's unpaired t-test. Data are presented as mean ± SEM. Abbreviations: Contra: contralateral hemisphere; Ipsi: ipsilateral hemisphere. (C) The simple linear regression analysis shows the linear correlation between the two evaluation methods. (D-G) Representative photomicrographs of H&E-stained sections show focal injury in the subcortical white matter in the ipsilateral hemispheres at 3 days after HI in PND 5 mice (D and E) but not in PND 9 mice (F and G) with a similar degree of injury. Arrows in (D) show subcortical white-matter injury. Arrows and star in (E) show focal gray-matter injury in the ipsilateral hemisphere of the PND 5 HI mouse brain.

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