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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Plasminogen in cerebrospinal fluid originates from circulating blood

Figure 6

Quantification of plasminogen in human cerebrospinal fluid. Cerebrospinal fluid (CSF) samples were collected from patients with Guillain-Barré syndrome (GBS, n = 15), multiple sclerosis (MS, n = 19) and noninflammatory neurological disease (NIND, n = 8). (A) Representative human CSF immunoblot showing peroxidase-conjugated monoclonal antibody directed against plasminogen kringle 1 (CPL15-PO). Electrophoresis of human plasminogen (Pg) (Mr = 92,000 Da), 10 μl of human plasma diluted 1:50 and 7 μg of total protein in CSF. (B) Box-and-whisker plot of human CSF plasminogen after immunoblot analysis and densitometric analysis. Results represent median (interquartile range) (P < 0.0001, one-way analysis of variance). *P < 0.05 for GBS versus MS and §P < 0.05 for GBS versus NIND (Bonferroni’s multiple-comparisons posttest).

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