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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Inflammation early in life is a vulnerability factor for emotional behavior at adolescence and for lipopolysaccharide-induced spatial memory and neurogenesis alteration at adulthood

Figure 4

Postnatal day 14 (PND14) neonatal lipopolysaccharide (LPS) decreases the phosphorylated glucocorticoid receptor/glucocorticoid receptor ratio in the prefrontal cortex at adulthood. Representative immunoblots corresponding to the phosphorylated form of glucocorticoid receptor (PGR) and total glucocorticoid receptor (GR) in the prefrontal cortex (A) and the hippocampus (B) of adult mice receiving either NaCl or LPS at PND14 are presented. Immunoblots were quantified and the ratios for PGR/GR (left graph panels) or GR/actin were calculated (right graph panels). Data are expressed as mean ± SEM (n = 10/group). *P <0.05, for NaCl compared to LPS. Plasma corticosterone levels were measured by radioimmunoassay (RIA) in the plasma (C). Data are expressed as mean ± SEM (n = 10/group). *P <0.05, for NaCl compared to LPS.

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